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mammalian uncoordinated 18 1  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc mammalian uncoordinated 18 1
    Downregulation of SNARE correlative proteins in the NAc contributed to the impairment of glutamatergic synaptic transmission. (a) Western blot showed the protein expression of STX1A, SNAP-25, VAMP2, <t>Munc18–1,</t> and NSF. (b) Quantitative analysis of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF comparing with GAPDH, the expression of VAMP2 and Munc18–1 had no change while that of STX1A, SNAP-25, and NSF was decreased in CFA group. The data are presented as the means ± SEM ( n = 5/group; * p < 0.05, ** p < 0.01 compared to the saline group). SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; NAc: nucleus accumbens; STX1A: Syntaxin 1A; SNAP: synaptosome-associated protein; VAMP2: vesicle-associated membrane protein 2; NSF: N-ethylmaleimide-sensitive factor; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; CFA: complete Freund’s adjuvant; SEM: standard error of mean; Munc18–1: mammalian uncoordinated <t>18–1.</t>
    Mammalian Uncoordinated 18 1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 91/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mammalian uncoordinated 18 1/product/Cell Signaling Technology Inc
    Average 91 stars, based on 12 article reviews
    mammalian uncoordinated 18 1 - by Bioz Stars, 2026-02
    91/100 stars

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    1) Product Images from "Chronic inflammatory pain decreases the glutamate vesicles in presynaptic terminals of the nucleus accumbens"

    Article Title: Chronic inflammatory pain decreases the glutamate vesicles in presynaptic terminals of the nucleus accumbens

    Journal: Molecular Pain

    doi: 10.1177/1744806918781259

    Downregulation of SNARE correlative proteins in the NAc contributed to the impairment of glutamatergic synaptic transmission. (a) Western blot showed the protein expression of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF. (b) Quantitative analysis of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF comparing with GAPDH, the expression of VAMP2 and Munc18–1 had no change while that of STX1A, SNAP-25, and NSF was decreased in CFA group. The data are presented as the means ± SEM ( n = 5/group; * p < 0.05, ** p < 0.01 compared to the saline group). SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; NAc: nucleus accumbens; STX1A: Syntaxin 1A; SNAP: synaptosome-associated protein; VAMP2: vesicle-associated membrane protein 2; NSF: N-ethylmaleimide-sensitive factor; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; CFA: complete Freund’s adjuvant; SEM: standard error of mean; Munc18–1: mammalian uncoordinated 18–1.
    Figure Legend Snippet: Downregulation of SNARE correlative proteins in the NAc contributed to the impairment of glutamatergic synaptic transmission. (a) Western blot showed the protein expression of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF. (b) Quantitative analysis of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF comparing with GAPDH, the expression of VAMP2 and Munc18–1 had no change while that of STX1A, SNAP-25, and NSF was decreased in CFA group. The data are presented as the means ± SEM ( n = 5/group; * p < 0.05, ** p < 0.01 compared to the saline group). SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; NAc: nucleus accumbens; STX1A: Syntaxin 1A; SNAP: synaptosome-associated protein; VAMP2: vesicle-associated membrane protein 2; NSF: N-ethylmaleimide-sensitive factor; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; CFA: complete Freund’s adjuvant; SEM: standard error of mean; Munc18–1: mammalian uncoordinated 18–1.

    Techniques Used: Transmission Assay, Western Blot, Expressing



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    mammalian uncoordinated 18 1  (Cell Signaling Technology Inc)
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    Cell Signaling Technology Inc mammalian uncoordinated 18 1
    Downregulation of SNARE correlative proteins in the NAc contributed to the impairment of glutamatergic synaptic transmission. (a) Western blot showed the protein expression of STX1A, SNAP-25, VAMP2, <t>Munc18–1,</t> and NSF. (b) Quantitative analysis of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF comparing with GAPDH, the expression of VAMP2 and Munc18–1 had no change while that of STX1A, SNAP-25, and NSF was decreased in CFA group. The data are presented as the means ± SEM ( n = 5/group; * p < 0.05, ** p < 0.01 compared to the saline group). SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; NAc: nucleus accumbens; STX1A: Syntaxin 1A; SNAP: synaptosome-associated protein; VAMP2: vesicle-associated membrane protein 2; NSF: N-ethylmaleimide-sensitive factor; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; CFA: complete Freund’s adjuvant; SEM: standard error of mean; Munc18–1: mammalian uncoordinated <t>18–1.</t>
    Mammalian Uncoordinated 18 1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mammalian uncoordinated 18 1/product/Cell Signaling Technology Inc
    Average 91 stars, based on 1 article reviews
    mammalian uncoordinated 18 1 - by Bioz Stars, 2026-02
    91/100 stars
    		  Buy from Supplier

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    Downregulation of SNARE correlative proteins in the NAc contributed to the impairment of glutamatergic synaptic transmission. (a) Western blot showed the protein expression of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF. (b) Quantitative analysis of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF comparing with GAPDH, the expression of VAMP2 and Munc18–1 had no change while that of STX1A, SNAP-25, and NSF was decreased in CFA group. The data are presented as the means ± SEM ( n = 5/group; * p < 0.05, ** p < 0.01 compared to the saline group). SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; NAc: nucleus accumbens; STX1A: Syntaxin 1A; SNAP: synaptosome-associated protein; VAMP2: vesicle-associated membrane protein 2; NSF: N-ethylmaleimide-sensitive factor; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; CFA: complete Freund’s adjuvant; SEM: standard error of mean; Munc18–1: mammalian uncoordinated 18–1.

    Journal: Molecular Pain

    Article Title: Chronic inflammatory pain decreases the glutamate vesicles in presynaptic terminals of the nucleus accumbens

    doi: 10.1177/1744806918781259

    Figure Lengend Snippet: Downregulation of SNARE correlative proteins in the NAc contributed to the impairment of glutamatergic synaptic transmission. (a) Western blot showed the protein expression of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF. (b) Quantitative analysis of STX1A, SNAP-25, VAMP2, Munc18–1, and NSF comparing with GAPDH, the expression of VAMP2 and Munc18–1 had no change while that of STX1A, SNAP-25, and NSF was decreased in CFA group. The data are presented as the means ± SEM ( n = 5/group; * p < 0.05, ** p < 0.01 compared to the saline group). SNARE: soluble N-ethylmaleimide-sensitive factor attachment protein receptor; NAc: nucleus accumbens; STX1A: Syntaxin 1A; SNAP: synaptosome-associated protein; VAMP2: vesicle-associated membrane protein 2; NSF: N-ethylmaleimide-sensitive factor; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; CFA: complete Freund’s adjuvant; SEM: standard error of mean; Munc18–1: mammalian uncoordinated 18–1.

    Article Snippet: The primary antibodies were as follows: rabbit IgG against Syntaxin 1A (STX1A, 1:1000, Cell Signaling Technology, USA), synaptosome-associated protein-25 (SNAP-25, 1:1000), vesicle-associated membrane protein 2 (VAMP2, 1:1000), mammalian uncoordinated 18–1 (Munc18–1, 1:1000), NSF (1:1000), VGLUT2(1:1000), mouse IgG against VGLUT1 (1:500, Millipore, USA), and mouse IgG against glyceraldehyde 3-phosphate dehydrogenase (GAPDH; 1:1000, Zhuang Zhi, China).

    Techniques: Transmission Assay, Western Blot, Expressing